abstract：:P2Y12 receptor inhibition in addition to aspirin is the cornerstone of treatment in patients with acute coronary syndromes (ACS) and those undergoing percutaneous coronary intervention (PCI). Despite advances in contemporary antithrombotic therapy, periprocedural thrombotic complications such as myocardial infarction ...

journal_title：Pharmacology & therapeutics

authors： Qamar A,Bhatt DL

更新日期：2016-03-01 00:00:00

abstract：:Canonical Wnt signaling is a highly conserved pathway with a prominent role in embryogenic development, adult tissue homeostasis, cell polarization, stem cell biology, cell differentiation, and proliferation. Furthermore, canonical Wnt signaling is of pivotal importance in the pathogenesis of a number of cancer types ...

journal_title：Pharmacology & therapeutics

authors： Roos J,Grösch S,Werz O,Schröder P,Ziegler S,Fulda S,Paulus P,Urbschat A,Kühn B,Maucher I,Fettel J,Vorup-Jensen T,Piesche M,Matrone C,Steinhilber D,Parnham MJ,Maier TJ

更新日期：2016-01-01 00:00:00

abstract：:Obesity and its metabolic resultant dysfunctions such as insulin resistance, hyperglycemia, dyslipidemia and hypertension, grouped as the "metabolic syndrome", are chronic inflammatory disorders that represent one of the most severe epidemic health problems. The imbalance between energy intake and expenditure, leading...

journal_title：Pharmacology & therapeutics

authors： Milbank E,Martinez MC,Andriantsitohaina R

更新日期：2016-01-01 00:00:00

abstract：:The understanding of renal fibrosis in chronic kidney disease (CKD) remains as a challenge. More than 10% of the population of developed countries suffer from CKD. Proliferation and activation of myofibroblasts and accumulation of extracellular matrix proteins are the main features of kidney fibrosis, a process in whi...

journal_title：Pharmacology & therapeutics

authors： Muñoz-Félix JM,González-Núñez M,Martínez-Salgado C,López-Novoa JM

更新日期：2015-12-01 00:00:00

abstract：:Aquaporin (AQP) water and solute channels have basic physiological functions throughout the human body. AQP-facilitated water permeability across cell membranes is required for rapid reabsorption of water from pre-urine in the kidneys and for sustained near isosmolar water fluxes e.g. in the brain, eyes, inner ear, an...

journal_title：Pharmacology & therapeutics

authors： Beitz E,Golldack A,Rothert M,von Bülow J

更新日期：2015-11-01 00:00:00

abstract：:In the last decade, there have been considerable advances in the understanding of the pathophysiology of malignant ventricular tachyarrhythmias (VT) and sudden cardiac death (SCD). Over 80% of SCD occurs in patients with organic heart disease. However, approximately 10%-15% of SCD occurs in the presence of structurall...

journal_title：Pharmacology & therapeutics

authors： El-Sherif N,Boutjdir M

更新日期：2015-11-01 00:00:00

abstract：:The receptors involved in bitter taste perception (bitter taste receptors--T2Rs) constitute a family of G-protein-coupled receptors, of which around 29 subtypes have been identified in humans. T2R expression was initially thought to be confined to the oral cavity but has recently been described in a range of other tis...

journal_title：Pharmacology & therapeutics

authors： Devillier P,Naline E,Grassin-Delyle S

更新日期：2015-11-01 00:00:00

abstract：:Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery that occurs in up to 60% of patients. POAF is associated with increased risk of cardiovascular mortality, stroke and other arrhythmias that can impact on early and long term clinical outcomes and health economics. Many factors such as...

journal_title：Pharmacology & therapeutics

authors： Zakkar M,Ascione R,James AF,Angelini GD,Suleiman MS

更新日期：2015-10-01 00:00:00

abstract：:The tumor microenvironment is increasingly recognized as a major factor influencing the success of therapeutic treatments and has become a key focus for cancer research. The progressive growth of a tumor results in an inability of normal tissue blood vessels to oxygenate and provide sufficient nutritional support to t...

journal_title：Pharmacology & therapeutics

authors： Siemann DW,Horsman MR

更新日期：2015-09-01 00:00:00

abstract：:Regenerative medicine using mesenchymal stem cells for the purposes of tissue repair has garnered considerable public attention due to the potential of returning tissues and organs to a normal, healthy state after injury or damage has occurred. To achieve this, progenitor cells such as pericytes and bone marrow-derive...

journal_title：Pharmacology & therapeutics

authors： Wong SP,Rowley JE,Redpath AN,Tilman JD,Fellous TG,Johnson JR

更新日期：2015-07-01 00:00:00

abstract：:Increasing epidemiological and experimental evidence implicates gestational infections as one important factor involved in the pathogenesis of several neuropsychiatric disorders. Corresponding preclinical model systems based upon maternal immune activation (MIA) by treatment of the pregnant female have been developed....

journal_title：Pharmacology & therapeutics

authors： Reisinger S,Khan D,Kong E,Berger A,Pollak A,Pollak DD

更新日期：2015-05-01 00:00:00

abstract：:Uncomplicated upper respiratory viral infections are the most common cause of days lost from work and school and exert a major economic burden. In susceptible individuals, however, common respiratory viruses, particularly human rhinoviruses, also can have a major impact on diseases that involve the lower airways, incl...

journal_title：Pharmacology & therapeutics

authors： Leigh R,Proud D

更新日期：2015-04-01 00:00:00

abstract：:The association between vitamin D and multiple sclerosis has (re)-opened new interest in nutrition and natural compounds in the prevention and treatment of this neuroinflammatory disease. The dietary amount and type of fat, probiotics and biologicals, salmon proteoglycans, phytoestrogens and protease inhibitor of soy,...

journal_title：Pharmacology & therapeutics

authors： Schmitz K,Barthelmes J,Stolz L,Beyer S,Diehl O,Tegeder I

更新日期：2015-04-01 00:00:00

abstract：:Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte recruitment is a process comprising several steps orchestrated by adhesion molecules, chemokines, cytokines and endogenous regulatory molecules. Distinct adhesive interactions between endothelial cells and leukocytes and signa...

journal_title：Pharmacology & therapeutics

authors： Mitroulis I,Alexaki VI,Kourtzelis I,Ziogas A,Hajishengallis G,Chavakis T

更新日期：2015-03-01 00:00:00

abstract：:The PI3K/Akt/mTOR pathway is the most frequently known activated aberrant pathway in human cancers. Pathologic activation can occur at multiple levels along the signaling pathway by a variety of mechanisms, including point mutations, amplifications, and inactivation of tumor suppressor genes. This pathway is also a kn...

journal_title：Pharmacology & therapeutics

authors： Bauer TM,Patel MR,Infante JR

更新日期：2015-02-01 00:00:00

abstract：:The vascular endothelium not only is a single monolayer of cells between the vessel lumen and the intimal wall, but also plays an important role by controlling vascular function and structure mainly via the production of nitric oxide (NO). The so called "cardiovascular risk factors" are associated with endothelial dys...

journal_title：Pharmacology & therapeutics

authors： Tousoulis D,Simopoulou C,Papageorgiou N,Oikonomou E,Hatzis G,Siasos G,Tsiamis E,Stefanadis C

更新日期：2014-12-01 00:00:00

abstract：:Activated platelets contribute to plaque formation within blood vessels in the early and late stages of atherogenesis, and therefore they have been proposed as risk factor for cardiovascular disease. Anti-platelet drugs, such as aspirin, are now the most prescribed pharmacological treatment in Europe. Certain dietary ...

journal_title：Pharmacology & therapeutics

authors： Bachmair EM,Ostertag LM,Zhang X,de Roos B

更新日期：2014-11-01 00:00:00

abstract：:Cardiovascular diseases cause more mortality and morbidity worldwide than any other diseases. Although many intracellular signaling pathways influence cardiac physiology and pathology, the mitogen-activated protein kinase (MAPK) family has garnered significant attention because of its vast implications in signaling an...

journal_title：Pharmacology & therapeutics

authors： Javadov S,Jang S,Agostini B

更新日期：2014-11-01 00:00:00

abstract：:Initially regarded as "epigenetic modifiers" acting predominantly through chromatin remodeling via histone acetylation, HDACIs, alternatively referred to as lysine deacetylase or simply deacetylase inhibitors, have since been recognized to exert multiple cytotoxic actions in cancer cells, often through acetylation of ...

journal_title：Pharmacology & therapeutics

authors： Bose P,Dai Y,Grant S

更新日期：2014-09-01 00:00:00

abstract：:The human epidermal growth factor receptor (HER) family members are targeted by a growing numbers of small molecules and monoclonal antibodies. Resistance against the epidermal growth factor receptor (EGFR) and HER2-targeting agents is a clinically relevant problem forcing research on optimizing targeting of the HER f...

journal_title：Pharmacology & therapeutics

authors： Kol A,Terwisscha van Scheltinga AG,Timmer-Bosscha H,Lamberts LE,Bensch F,de Vries EG,Schröder CP

更新日期：2014-07-01 00:00:00

abstract：UNLABELLED:Preclinical animal models are useful tools to better understand tumor initiation and progression and to predict the activity of an anticancer agent in the clinic. Ideally, these models should recapitulate the biological characteristics of the tumor and of the related tumor microenvironment (e.g. vasculature,...

journal_title：Pharmacology & therapeutics

authors： Wartha K,Herting F,Hasmann M

更新日期：2014-06-01 00:00:00

abstract：:The cardiovascular system is capable of robust changes in response to physiologic and pathologic stimuli through intricate signaling mechanisms. The area of metabolism has witnessed a veritable renaissance in the cardiovascular system. In particular, the post-translational β-O-linkage of N-acetylglucosamine (O-GlcNAc)...

journal_title：Pharmacology & therapeutics

authors： Dassanayaka S,Jones SP

更新日期：2014-04-01 00:00:00

abstract：:Aspirin is integral to the secondary prevention of cardiovascular disease and acts to impair the development of platelet-mediated atherothromboembolic events by irreversible inhibition of platelet cyclooxygenase-1 (COX-1). Inhibition of this enzyme prevents the synthesis of the potent pro-aggregatory prostanoid thromb...

journal_title：Pharmacology & therapeutics

authors： Floyd CN,Ferro A

更新日期：2014-01-01 00:00:00

abstract：:Increasing evidence of a critical role played by the bronchial epithelium in airway homeostasis is opening new therapeutic avenues. Its unique situation at the interface with the environment suggests that the subtle regulation orchestrated by the epithelium between tolerance and specific immune response might be impai...

journal_title：Pharmacology & therapeutics

authors： Gras D,Chanez P,Vachier I,Petit A,Bourdin A

更新日期：2013-12-01 00:00:00

abstract：:Evidence that the delta opioid receptor (DOR) is an attractive target for the treatment of brain disorders has strengthened in recent years. This receptor is broadly expressed in the brain, binds endogenous opioid peptides, and shows as functional profile highly distinct from those of mu and kappa opioid receptors. Ou...

journal_title：Pharmacology & therapeutics

authors： Chu Sin Chung P,Kieffer BL

更新日期：2013-10-01 00:00:00

abstract：:Integrins are heterodimeric cell surface receptors, which principally mediate the interaction between cells and their extracellular microenvironments. Because of their pivotal roles in cancer proliferation, survival, invasion and metastasis, integrins have been recognized as promising targets for cancer treatment. As ...

journal_title：Pharmacology & therapeutics

authors： Onodera Y,Nam JM,Sabe H

更新日期：2013-10-01 00:00:00

abstract：:Minor groove binders are small molecules that form strong complexes with the minor groove of DNA. There are several structural types of which distamycin and netropsin analogues, oligoamides built from heterocyclic and aromatic amino acids, and bis-amidines separated by aromatic and heterocyclic rings are of particular...

journal_title：Pharmacology & therapeutics

authors： Barrett MP,Gemmell CG,Suckling CJ

更新日期：2013-07-01 00:00:00

abstract：:Hypertension is an epidemic health concern and a major risk factor for the development of cardiovascular disease. Although there are available treatment strategies for hypertension, numerous hypertensive patients do not have their clinical symptoms under control and it is imperative that new avenues to treat or preven...

journal_title：Pharmacology & therapeutics

authors： de Kloet AD,Krause EG,Shi PD,Zubcevic J,Raizada MK,Sumners C

更新日期：2013-06-01 00:00:00

abstract：:Cell proliferation is an essential mechanism for growth, development and regeneration of eukaryotic organisms; however, it is also the cause of one of the most devastating diseases of our era: cancer. Given the relevance of the processes in which cell proliferation is involved, its regulation is of paramount importanc...

journal_title：Pharmacology & therapeutics

authors： Diaz-Moralli S,Tarrado-Castellarnau M,Miranda A,Cascante M

更新日期：2013-05-01 00:00:00

abstract：:Enhancing the effects of endogenously-released cannabinoid ligands in the brain might provide therapeutic effects more safely and effectively than administering drugs that act directly at the cannabinoid receptor. Inhibitors of fatty acid amide hydrolase (FAAH) prevent the breakdown of endogenous ligands for cannabino...

journal_title：Pharmacology & therapeutics

authors： Panlilio LV,Justinova Z,Goldberg SR

更新日期：2013-04-01 00:00:00

abstract：:Metabolic syndrome has been described as the association of insulin resistance, hypertension, hyperlipidemia and obesity. Its prevalence increased dramatically, mainly in developed countries. Animal models are essential to understand the pathophysiology of this syndrome. This review presents the murine models of metab...

journal_title：Pharmacology & therapeutics

authors： Fellmann L,Nascimento AR,Tibiriça E,Bousquet P

更新日期：2013-03-01 00:00:00

abstract：:There is clear evidence that CB(2), historically referred to as the peripheral cannabinoid receptor, mediates many of the immune modulatory effects of cannabinoids. However, cannabinoid receptors cannot be classified simply as central or peripheral since CB(2) has been shown to play a role in the central nervous syste...

journal_title：Pharmacology & therapeutics

authors： Kaplan BL

更新日期：2013-03-01 00:00:00

abstract：:The neurotransmitter serotonin (5-hdroxytryptamine; 5-HT) has been implicated in the pathophysiology and treatment of major depression since the serendipitous discovery of antidepressant drugs in the 1950s. However, despite the generalised use of serotonin-enhancing drugs, such as the selective serotonin reuptake inhi...

journal_title：Pharmacology & therapeutics

authors： Artigas F

更新日期：2013-01-01 00:00:00

abstract：:Substantial progress in the identification of genes encoding for a large number of proteins responsible for various aspects of neurotransmitter release, postsynaptic detection and downstream signaling, has advanced our understanding of the mechanisms by which neurons communicate and interact. Nicotinic acetylcholine r...

journal_title：Pharmacology & therapeutics

authors： Hurst R,Rollema H,Bertrand D

更新日期：2013-01-01 00:00:00

abstract：:Dipeptidyl peptidase 4 (DPP4, DPPIV, CD26, EC 3.4.14.5) was discovered more than four decades ago as a serine protease that cleaves off N-terminal dipeptides from peptide substrates. The development of potent DPP4 inhibitors during the past two decades has led to the identification of DPP4 as a target in the treatment...

journal_title：Pharmacology & therapeutics

authors： Matheeussen V,Jungraithmayr W,De Meester I

更新日期：2012-12-01 00:00:00

abstract：:Hypoxia inducible factor (HIF) is an oxygen-sensitive transcription factor that enables aerobic organisms to adapt to hypoxia. This is achieved through the transcriptional activation of up to 200 genes, many of which are critical to cell survival. Under conditions of normoxia, the hydroxylation of HIF by prolyl hydrox...

journal_title：Pharmacology & therapeutics

authors： Ong SG,Hausenloy DJ

更新日期：2012-10-01 00:00:00

abstract：:Diabetes is a debilitating disease characterized by chronic hyperglycemia and is often associated with obesity. With diabetes and obesity incidence on the rise, it is imperative to develop novel therapeutics that will not only lower blood glucose levels, but also combat the associated obesity. The G protein-coupled re...

journal_title：Pharmacology & therapeutics

authors： Cho YM,Merchant CE,Kieffer TJ

更新日期：2012-09-01 00:00:00

abstract：:Dysregulation of inflammation is central to the pathogenesis of innumerable human diseases. Understanding and tracking the critical events in inflammation are crucial for disease monitoring and pharmacological drug discovery and development. Recent progress in molecular imaging has provided novel insights into spatial...

journal_title：Pharmacology & therapeutics

authors： Dorward DA,Lucas CD,Rossi AG,Haslett C,Dhaliwal K

更新日期：2012-08-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in people with severe mental disorders, and rates are proportionally greater than for other diseases such as cancer. Reports of sudden death in patients receiving antipsychotic treatment have raised concerns about the safety of antipsychotic drugs, leading to a numb...

journal_title：Pharmacology & therapeutics

authors： Leung JY,Barr AM,Procyshyn RM,Honer WG,Pang CC

更新日期：2012-08-01 00:00:00

abstract：:Elevated low density lipoprotein cholesterol (LDL-C) levels have been associated with an increased risk for cardiovascular disease (CVD). Despite a 25-30% reduction in CVD risk with LDL-C reducing strategies, there is still a significant residual risk. Moreover, achieving target LDL-C values in individuals at high CVD...

journal_title：Pharmacology & therapeutics

authors： Joy TR

更新日期：2012-07-01 00:00:00